Everton are impressively on 14 points after seven games and could stretch six points clear of the Hammers with a victory in the race for European football.
Here’s all the key information you need to know ahead of kick-off.
What’s the team news?
The Blues are sweating on the fitness of Lucas Digne.
The left-back was forced to pull out of France’s squad during the international break with a hamstring injury. As a result, he missed their Nations League final triumph over Spain.
There are also concerns about whether Yerry Mina will return from Colombia duty in time for the game.
They play Ecuador at 22.00 BST on Thursday evening.
However, Everton should be boosted by the return of a trio of key players.
Richarlison (knee), Dominic Calvert-Lewin (quad) and Seamus Coleman (hamstring) were back training individually before the hiatus of fixtures.
If Coleman is back and Digne is out, Ben Godfrey will deputise at left-back. Meanwhile, Mason Holgate will feature in central defence is Mina is absent.
Alex Iwobi missed the 1-1 draw against Manchester United after failing a late fitness but could again be available.
Fabian Delph remains a doubt with a shoulder problem, as does Andre Gomes because of a calf complaint.
What about West Ham?
Vladimír Coufal pulled out of Czech Republic duty because of a groin issue.
That was only described as minor, though, and he could recover in time for the trip to Merseyside. .
Ryan Fredericks should also return for the Londoners.
Everton (4-4-2): Pickford, Coleman, Holgate, Keane, Godfrey, Townsend, Doucoure, Allan, Gray, Calvert-Lewin, Richarlison.
West Ham (4-2-3-1): Fabianski, Coufal, Zouma, Ogbonna, Cresswell, Rice, Soucek, Bowen, Benrahma, Fornals, Antonio.
Is the match on TV?
Yes. The game will be broadcast on Sky Sports Main Event and Sky Sports Premier League.
Coverage starts at 13.00 on the latter, with the clash being broadcast from kick-off on Main Event.
Who’s commentating and who’s presenting?
Bill Leslie will be on the microphone alongside Alan Smith.
In the studio, regular Super Sunday presenter will be joined by Graeme Souness, Ledley King and Michael Dawson.
Can I stream the match?
Yes. Sky Sports subscribers can stream the game via Sky Go.
Can I stream the match if I don’t subscribe to Sky Sports?
Yes. You can purchase a Now TV Sports Day pass for £9.98.
How can I watch highlights?
Extended highlights will be on Match of the Day on Sunday evening, with the programme starting at 22.30 on BBC One.
For all the post-match analysis, follow our coverage on LiverpoolWorld.