Everton boss Rafa Benitez. Picture: George Wood/Getty Images
The Toffees will head into the Loftus Road encounter as favourites against their Championship hosts.
Here’s all the key information you need to know ahead of the tie.
What's the team news?
Benitez will be without four of his key players yet again.
Richarlison (knee), Dominic Calvert-Lewin (quad), Seamus Coleman (hamstring) and Jordan Pickford (shoulder) are all absent for the next couple of weeks.
Fabian Delph continues his recovery from a shoulder injury and Jean-Philippe Gbamin remains sidelined.
Fringe players such as Jonjoe Kenny, Tom Davies, Anthony Gordon and Jarrad Branthwaite could all feature.
Could anyone make a debut?
Salomon Rondon is Everton's only fit senior striker and he may not be risked.
It could, therefore, hand an opportunity to Ellis Simms to make his bow.
The 19-year-old netted 10 goals in 24 games while on loan at Blackpool last season, helping them earn League One promotion.
Simms has only just recovered from a hamstring injury but was on the bench in the defeat at Villa.
What about the opposition?
Sam Field (knee) and Luke Wallace (hamstring) are both confirmed absentees for QPR.
Luke Amos has recently recovered from a long-term setback and could feature at some point.
QPR (3-4-3): Archer, Kakay, Dickie, Dunne; Odubajo, Thomas, Dozzell, McCallum, Chair, Austin Willock
Everton(3-4-3): Begovic, Godfrey, Holgate, Keane, Kenny, Davis, Gomez, Branthwaite, Iwobi, Simms, Gordon.
Is the match on TV?
No. The game isn't being broadcast live.
Can I stream the match?
No. As the game hasn't been selected for live broadcast, you cannot stream the game.
If you're a Sky Sports subscriber, Gilette Soccer Special will be showing all the goals that go in from each match in the Carabao Cup. The programme is being broadcast on Sky Sports Premier League and Sky Sports News.
How can I watch highlights?
Extended highlights will be on Quest TV on Wednesday, with the programme starting at 22.30.
For all the post-match analysis, follow our coverage on LiverpoolWorld.