And with Jurgen Klopp’s side already out of the Premier League title race, along with the Carabao Cup, the historic competition is just one of two trophies they can still win this season.
Liverpool have endured a stuttering season and the 3-1 loss to Brentford earlier this week leaves them sixth in the table and in a battle to finish in the Champions League places.
But the FA Cup can prove somewhat of a distraction and Klopp will be eyeing a victory.
Ahead of the clash, here is the latest injury news at Anfield.
1. KIRKBY, ENGLAND - AUGUST 18: (THE SUN OUT, THE SUN ON SUNDAY OUT) Roberto Firmino and Virgil van Dijk of Liverpool during a training session at AXA Training Centre on August 18, 2022 in Kirkby, England. (Photo by Andrew Powell/Liverpool FC via Getty Images)
Virgil van Dij, left, and Roberto Firmino in Liverpool training. Picture: Andrew Powell/Liverpool FC via Getty Images
2. Virgil van Dijk - hamstring
The centre-back’s issue he suffered in the 3-1 loss against Brentford is worse than Liverpool first feared. He was due to see a specalist on Wednesday. Potential return: N/A. Photo: Clive Rose/Getty Images
3. Roberto Firmino - calf
The Brazil international has not played in any of Liverpool’s four games since the season restarted. Klopp has said that Firmino’s issue was not too serious. Potential return: Wolves, Saturday 7 January. Photo: Nick Taylor/Liverpool FC/Liverpool FC via Getty Images
4. James Milner - hamstring
The vice-captain has missed the past three games after coming off in the 3-2 Carabao Cup loss to Man City. Klopp did expect Milner to only be absent for a couple of games. Potential return: Wolves, Saturday 7 January. Photo: Stu Forster/Getty Images