The Reds have fallen behind in the title race and are wary they can’t drop any more points if they’re to challenge Manchester City.
Jurgen Klopp’s men were held to a goalless draw against Arsenal in the Carabao Cup semi-final first leg on Sunday.
Meanwhile, Brentford were beaten 4-1 by Southampton last time out.
When the two sides met in the reverse fixture in September, they played out an entertaining 3-3 draw.
Here is all the key information you need to know ahead of kick-off.
What’s Liverpool’s team news?
The Reds will once again be without key forwards Mo Salah and Sadio Mane.
They are at the African Cup of Nations, along with Naby Keita.
Klopp revealed that Divock Origi is back outside running but this game may come too soon.
Harvey Elliott is close to returning to first-team training after fracturing his ankle in September.
What’s Brentford’s team news?
Ex-Liverpool winger Sergi Canos came off in the Bees’ loss at Southampton with a hamstring injury.
However, he should be available according to manager Thomas Frank, along with Rico Henry.
Frank Onyeka is away at AFCON, while David Raya, Josh Dasilva Charlie Goode and Mathias Jorgensen are absentees.
Liverpool (4-3-3): Alisson, Alexander-Arnold, Matip, van Dijk, Robertson, Fabinho, Henderson, Jones, Firmino, Jota, Minamino
Brentford (4-4-2): Fernandez, Pinnock, Jansson, Sorensen, Roerslev, Baptiste, Norgaard, Jensen, Canos, Mbuemo, Toney.
Is the match on TV?
No. The match has not been selected for live broadcast in the UK.
Can I stream the match?
Unfortunately not because the game is not being broadcast live in the UK.
How can I watch highlights?
Match of the Day Two will show highlights of all games on Sunday evening. The programme starts at 22.30 on BBC One.
For all of the post-match analysis, follow our coverage on LiverpoolWorld.