It's a game that the entire football world will have eyes on.
To say Liverpool's showdown against Manchester City is seismic is an understatement. It's an encounter that could well be a Premier League title decider.
Just one point separates the modern-day rivals. The Reds sit at the summit of the table but City are breathing down their necks. To make the game even more intriguing, Arsenal could well be at the top of the table come kick-off should they beat Brentford.
And another sub-plot is that it's set to be the last time Jurgen Klopp and Pep Guardiola are pitted against each other, with the former stepping down as Liverpool manager at the end of the season.
Ahead of the fixture, here's an early look at the team news for both sides.
1. Lisandro Martinez - out
The Man Utd defender remains unavailable until at least next month with a knee injury.
2. Mason Mount - out
The £60m summer signing has endured a difficult first season at Old Trafford and has not played since November.
3. Luke Shaw - out
The left-back has a muscle issue and may not play again this season.
4. Tyrell Malacia - out
The left-back has not made a single outing this season because of a knee injury.