The Reds were held to a 0-0 stalemate against Arsenal in the Carabao Cup semi-final first leg last Thursday.
Much has been made about the absence of Mo Salah and Sadio Mane, who are both at the African Cup of Nations - along with Naby Keita.
Salah and Mane have bagged a combined 31 goals this season but Liverpool struggled for creativity without them.
Jurgen Klopp now has to find the solutions to ensure the Reds return to winning ways and keep the pressure on leaders Manchester City.
When Liverpool played Brentford in the reverse fixture in September, six goals were netted in an entertaining 3-3 draw.
But the Bees were thrashed 4-1 by Southampton earlier this week and will want a big response.
Here’s how we think Liverpool will line-up for the game.