The Toffees sit just one place and one point above the drop zone after their undeserved 1-0 loss to Manchester City at the weekend.
But victory for Frank Lampard’s men against the Wood will see them move within just one win of a Wembley semi-final.
Luke Garrard’s non-league outfit are 78 places below in the football pyramid.
Still, after knocking out Championship high-fliers Bournemouth in the last round, the visitors will have their tails up.
Here is all the key information needed ahead of kick-off.
Everton team news
Lampard will be without eight first-team players against Boreham Wood.
Ben Godfrey continues his comeback from a hamstring problem while Fabian Delph is back on the grass as he looks to return from a thigh issue.
Yerry Mina (quad) and Tom Davies (hamstring) are long-term casualties.
January arrivals Donny van de Beek, Dele Alli and Anwar El Ghazi are all cup-tied.
Vitaliy Mykolenko will start for Everton while a debut could be handed to Nathan Patterson.
Boreham Wood team news
Defender Jamal Fyfield has been out with a hamstring issue but could return for the visitors.
Nathan Ashmore, who quit his job at Nando's to go into full-time football - is back having been absent for 16 weeks but may not start.
He was at Portsmouth during his youth days.
Kane Smith will also be desperate to play against his boyhood club.
However, the full-back has been sidelined for the past two weeks.
Everton: Begovic, Patterson, Holgate, Branthwaite, Mykolenko, Allan, Onyango, Gomes, Dobbin, Rondon, Townsend.
Boreham Wood: Ashmore, Stevens, Evans, Stephens, Lewis, Comley, Raymond, Rees, Mendy, Marsh, Boden
Is the game on TV?
Yes. The game is being broadcast live on ITV. Coverage starts at 19.30.
Can I stream the game?
Yes. You can stream the match on ITV Hub.
How can I watch highlights?
The FA Cup's official Youtube channel will have highlights of all fifth-round games.