The PSG striker was also joined by Bayern Munich striker Robert Lewandowski, who also was against the idea of a biennial World Cup.
Mbappe has great affiliation with the tournament, as his France side went all the way to lift their first World Cup since 1998, with the forward joining an illustrious list including Pele as teenagers to score in a final.
FIFA planned to introduce a World Cup every two years as a means to generate serious incomes, and they planned to tell delegates that a biennial World Cup could generate £3.3 billion.
Speaking at the Globe Soccer Awards, Mbappe said: “The World Cup is the World Cup, it’s a special thing because it’s something [held] every four years.
“If you hold it every two years, it can start to be normal to play [in the] World Cup. I want to say that’s not normal. That [should be] something amazing.
“We play over 60 games in a year. You have Euros, the World Cup, now the Nations League - so many competitions. We are happy to play but when it’s too much, it’s too much. We have to recover, we have to stay relaxed.
“If people want to see quality in the game, the emotion, to see what makes the beauty of football, I think we have to respect the health of players.”
He echoed the concerns that Klopp also had over the new plans proposed.
The Liverpool manager said it “wasn’t right” to make players play a World Cup every two years.
Klopp has never shied away from making his true feelings known, and recently received backlash on social media as he bemoaned the hectic winter schedule around Christmas in the Premier League.
Speaking back in September, Klopp said over plans for a World Cup every two years: “There is no other sport in the world with such a relentless calendar. No physical sport. There are more demanding sports like athletics and marathons but they don’t run 20 or 30 or 40 a year.
“We all know why it’s happening. Whatever people say that it’s about giving different countries opportunities, in the end it’s all about money, that’s how it is.
“That’s fine. But in the end, at one point somebody has to start understanding that without the players – the most important ingredients of this wonderful game – we cannot play it. Nobody is more important than the players.
“Imagine if every two years there is a World Cup and there will be a European Championship every two years. That means for top class players they play every year a big tournament.”